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Yun Yen Selected Research

GTI2040

10/2016A phase I pharmacodynamic study of GTI-2040, an antisense oligonucleotide against ribonuclotide reductase, in acute leukemias: a California Cancer Consortium study.
4/2011A phase II study of the antisense oligonucleotide GTI-2040 plus docetaxel and prednisone as first-line treatment in castration-resistant prostate cancer.
11/2009Phase I trial of GTI-2040, oxaliplatin, and capecitabine in the treatment of advanced metastatic solid tumors: a California Cancer Consortium Study.
9/2009A phase I/II study of GTI-2040 plus docetaxel as second-line treatment in advanced non-small cell lung cancer: a study of the PMH phase II consortium.
5/2006Analysis of ribonucleotide reductase M2 mRNA levels in patient samples after GTI-2040 antisense drug treatment.

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Yun Yen Research Topics

Disease

157Neoplasms (Cancer)
04/2022 - 11/2002
42Breast Neoplasms (Breast Cancer)
12/2021 - 01/2003
20Carcinogenesis
07/2021 - 08/2005
17Neoplasm Metastasis (Metastasis)
01/2021 - 11/2006
15Hepatocellular Carcinoma (Hepatoma)
04/2022 - 09/2005
12Colorectal Neoplasms (Colorectal Cancer)
01/2021 - 11/2005
9Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2021 - 09/2005
9Prostatic Neoplasms (Prostate Cancer)
01/2021 - 09/2009
8Pancreatic Neoplasms (Pancreatic Cancer)
01/2021 - 02/2010
7Starvation
01/2021 - 11/2005
7Multiple Myeloma
03/2020 - 01/2005
7Hypoxia (Hypoxemia)
01/2017 - 02/2009
6Carcinoma (Carcinomatosis)
01/2021 - 03/2006
6Liver Neoplasms (Liver Cancer)
06/2020 - 09/2009
6Squamous Cell Carcinoma of Head and Neck
01/2013 - 05/2009
5Stomach Neoplasms (Stomach Cancer)
06/2021 - 07/2012
5Cholangiocarcinoma
04/2020 - 06/2004
4Mitochondrial Diseases (Mitochondrial Disease)
01/2021 - 09/2014
4Adenocarcinoma
10/2019 - 03/2005
4Glioblastoma (Glioblastoma Multiforme)
09/2019 - 01/2014
4Glioma (Gliomas)
09/2019 - 01/2014
4Urinary Bladder Neoplasms (Bladder Cancer)
09/2019 - 01/2007
4Ovarian Neoplasms (Ovarian Cancer)
01/2019 - 10/2004
4Colonic Neoplasms (Colon Cancer)
01/2017 - 10/2003
4Lymphoma (Lymphomas)
06/2011 - 05/2005
3Triple Negative Breast Neoplasms
12/2021 - 06/2020
3Leukemia
04/2021 - 05/2011
3Ataxia Telangiectasia (Louis Bar Syndrome)
01/2021 - 12/2007
2Hematologic Neoplasms (Hematological Malignancy)
06/2021 - 12/2013
2Infections
01/2021 - 03/2016
2Pain (Aches)
01/2021 - 11/2014
2Mouth Neoplasms (Oral Cancer)
01/2021 - 01/2017
2Diarrhea
01/2021 - 02/2007
2Rhabdoid Tumor (Rhabdoid Tumors)
03/2020 - 03/2014

Drug/Important Bio-Agent (IBA)

32Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
01/2019 - 01/2003
31Proteins (Proteins, Gene)FDA Link
12/2021 - 05/2005
29Biomarkers (Surrogate Marker)IBA
03/2022 - 11/2006
18GemcitabineFDA Link
10/2019 - 11/2002
15Messenger RNA (mRNA)IBA
12/2021 - 01/2003
14Small Interfering RNA (siRNA)IBA
01/2017 - 07/2006
13Pharmaceutical PreparationsIBA
04/2021 - 01/2004
12DNA (Deoxyribonucleic Acid)IBA
03/2016 - 01/2003
11Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2018 - 01/2005
9MicroRNAs (MicroRNA)IBA
01/2021 - 06/2011
9IT-101IBA
10/2019 - 07/2009
8Phosphotransferases (Kinase)IBA
07/2021 - 04/2012
8CamptothecinIBA
10/2019 - 07/2009
8Estrogen ReceptorsIBA
06/2017 - 05/2004
7Arginine (L-Arginine)FDA Link
07/2021 - 04/2014
7Biological ProductsIBA
01/2019 - 11/2005
6EnzymesIBA
06/2021 - 04/2011
6Bortezomib (Velcade)FDA Link
03/2020 - 03/2006
6Cisplatin (Platino)FDA LinkGeneric
01/2019 - 01/2003
6PlatinumIBA
08/2016 - 11/2002
63-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)IBA
06/2013 - 10/2004
5PolymersIBA
10/2019 - 07/2009
52- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA
10/2019 - 07/2009
5Doxorubicin (Adriamycin)FDA LinkGeneric
01/2017 - 09/2004
5GTI2040IBA
10/2016 - 05/2006
5Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA
06/2010 - 01/2005
4MPT0L145IBA
12/2021 - 05/2016
4Oxaliplatin (Eloxatin)FDA LinkGeneric
01/2021 - 03/2007
4Hydroxyurea (Hydrea)FDA LinkGeneric
01/2021 - 11/2002
4Capecitabine (Xeloda)FDA Link
01/2021 - 05/2006
4Argininosuccinate Synthase (Argininosuccinate Synthetase)IBA
01/2021 - 04/2014
4RNA (Ribonucleic Acid)IBA
01/2021 - 03/2012
4Indicators and Reagents (Reagents)IBA
01/2020 - 07/2010
4Therapeutic UsesIBA
01/2020 - 01/2009
4CyclodextrinsIBA
10/2019 - 07/2012
4Gefitinib (Iressa)FDA Link
09/2019 - 09/2005
4Carboplatin (JM8)FDA LinkGeneric
01/2015 - 10/2004
4Calcibiotic Root Canal SealerIBA
05/2013 - 11/2005
3ChromatinIBA
06/2021 - 09/2014
3Histone Deacetylase InhibitorsIBA
06/2021 - 05/2008
3TeaIBA
01/2021 - 01/2007
3PHY 906IBA
01/2021 - 10/2009
3Antineoplastic Agents (Antineoplastics)IBA
06/2020 - 01/2003
3Proteasome InhibitorsIBA
03/2020 - 04/2012
3AntibodiesIBA
01/2020 - 10/2006
3TOR Serine-Threonine KinasesIBA
01/2019 - 04/2011
3CateninsIBA
01/2019 - 08/2015
3IntegrinsIBA
01/2016 - 12/2014
3PeroxiredoxinsIBA
01/2014 - 11/2005
3ribonucleotide reductase M2IBA
10/2011 - 05/2006
3Docetaxel (Taxotere)FDA Link
04/2011 - 12/2003
2entinostat (MS 275)IBA
06/2021 - 06/2020
2Histone Deacetylases (Histone Deacetylase)IBA
06/2021 - 01/2021
2N- (2- amino- 5- fluorobenzyl)- 4- (N- (pyridine- 3- acrylyl)aminomethyl)benzamideIBA
04/2021 - 06/2020
2VimentinIBA
01/2021 - 01/2013
2Histones (Histone)IBA
01/2021 - 09/2014
2Fluorouracil (Carac)FDA LinkGeneric
01/2021 - 01/2017
2Peptides (Polypeptides)IBA
01/2021 - 11/2012
2Cadherins (E-Cadherin)IBA
01/2021 - 04/2015
2Proteasome Endopeptidase Complex (Proteasome)IBA
03/2020 - 03/2012
2Ligases (Synthetase)IBA
01/2020 - 11/2017

Therapy/Procedure

47Therapeutics
12/2021 - 09/2005
28Drug Therapy (Chemotherapy)
12/2021 - 01/2003
6Radiotherapy
01/2018 - 05/2004
3Castration
01/2021 - 04/2011
2Intravenous Injections
01/2021 - 05/2012